MALDI plates with custom antibodies and other affinity molecules

Generic depiction of the Affinity MALDI chip technology

A/Preparation of MALDI protein chips by ion landing
B/Protein chip with sampled affinity partner (green) after the remaining serum/plasma was washed
C/Protein chip with MALDI matrix (yellow). Standard MALDI/MS is performed from each sample spot
D/MALDI-MS spectrum of enriched analyte. The spectrum shows model analytes α1 and α2 and no background peaks as the interfering components of serum/plasma were washed-off.